Ronaldo notched his first Serie A hat trick in the one-sided rout.
The Portugal skipper, who started the game upfront with Paulo Dybala, was quick to react following a poor pass from defender Ragnar Klavan before rounding keeper Robin Olsen and opening the scoring.
The visitor’s almost equalized on the hour mark as Nahitan Nandez produced an excellent cross for Giovanni Simeone at the back post but the striker’s header bounced off the crossbar.
Juve reacted fast from the wake-up call and an inspired Dybala went on a searching run, beating three defenders before being taken down by midfielder Marko Rog in the Cagliari box.
The Argentine was quickly involved as his solo run from the left-wing resulted in Juve’s third as Higuain cut in and drilled past Olsen.
With Cagliari well and truly beaten Ronaldo was seeking his first hat-trick in black and white in the Serie A.
As Ronaldo began the decade with a hat-trick in his TENTH competition, fans hailed the Portuguese icon.